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Luisa Carrer Several of these derangements lead to imbalances in metabolites, together with S-adenosylmethionine , α-ketoglutarate (αKG), and acetyl-CoA which are crucial to the regulation of epigenetic landscapes. They are substrate (SAM, acetyl-CoA) or substrates (αKG) for enzymes that modify chromatin conformation and regulate gene expression. In particular, we demonstrated that the availability of acetyl-CoA ... Read More